负责人：黄国英
秘 书：吴静燕
电 话：（021）64931916
E-mail：yjsh@fudan.edu.cn
二级学科：儿科学
研究方向
1.心血管方向：
儿童心血管疾病包括先天性心脏病、川崎病冠状动脉病变、心肌病、心律失常等的病因学、发病机制、诊断和早期干预研究。
2.肾脏方向：
肾脏尿路发育畸形的遗传学发病和调控机制、蛋白尿靶向新药的探讨和应用、肾损伤的干细胞修复机制研究、遗传性肾脏疾病的生物信息学研究、遗传性肾脏病新致病基因的分子机制、肾脏发育的分子调控机制、肾脏衰老的机制
3.新生儿方向：
脑发育与损伤修复机制、儿童遗传病新致病基因的发现与功能研究、遗传病的基因治疗、早产儿神经发育与脑白质损伤防治
4.神经方向：
全基因组序列与疾病表型分型、神经遗传学、癫痫
5.儿外科方向：
胆道闭锁表观遗传学调控机制（DNA甲基化、非编码RNA等调控机制）、新型胆道闭锁动物模型构建、胆道闭锁宏基因组研究、出生缺陷疾病的病因与发病机制研究、小儿外科胚胎源性疾病（畸形与肿瘤）的发病机制与治疗
6.神经外科方向：
神经肿瘤基因研究、神经发育，人工智能
7.肝病方向：
胆汁淤积症新致病基因鉴定、胆汁淤积症诊断和预后生物标志物发现、遗传性胆汁淤积症致病机理和新治疗靶标、iPS肝细胞定向分化
8.皮肤病学方向：
遗传性皮肤病发病分子机制和治疗研究、特应性皮炎发病分子机制研究
9.儿童保健科方向：
孤独症谱系障碍早期诊治
10.放射影像方向：
儿童脑损伤脑功能与结构分析、肿瘤影像组学、生长发育影像人工智能分析
11.其他：
小鼠模型（遗传与发育）、生物显微成像
膜蛋白相互作用高通量筛选及生物功能分析、肿瘤免疫治疗药物及抗体开发、蛋白相互作用大数据分析
调控大脑神经发育的关键表观遗传机制、儿童脑胶质瘤的病理机制、神经嵴细胞的分化和迁移机制
本专业领域内主要专家：
黄国英、桂永浩、王艺、徐虹、郑珊、陈超、王建设、严卫丽、余发星、罗敏、丰伟军、李昊、饶佳、徐秀、董岿然、乔中伟、黄涛生、刘芳、沈茜、董瑞、周玉峰、王建设、耿红全、李明、李智平等
Introduction to Postdoctoral Mobile Station
Children's Hospital of Fudan University
Person in charge: Prof. Guoying Huang
Secretary: Jingyan Wu
Tel: 86-21-64931916
E-mail: yjsh@fudan.edu.cn
Secondary discipline: Pediatrics
Research field：
1.Cardiology and Cardiac Sergery direction
Etiology, pathogenesis, diagnosis, and early intervention of congenital heart disease, Kawasaki disease with coronary artery disease, cardiomyopathy, cardiac arrhythmia, etc
2.Nephrology direction
●Genetic pathogenesis and regulation mechanism of renal urinary tract developmental dysplasia
●Discussion and application of new drugs targeting proteinuria
●Mechanisms of stem cell repair renal injury
●Bioinformatics research on hereditary renal disease
●Molecular mechanism of new pathogenic genes in hereditary renal diseases
●Molecular regulation mechanism of renal development
●The mechanism of kidney aging
3.Neonatology direction
●The mechanism of brain development and injury repair
●Explore new pathogenic genes of children hereditary diseases and study of their functions
●Gene therapy for genetic diseases
●Study the neurodevelopment of premature infants，prevention and treatment of cerebral white matter injury
4.Neurology direction
●Complete genome sequence and disease phenotype classification
●Neurogenetics
●Epileptic
5.Pediatric Surgery direction
●Epigenetic regulation in biliary atresia (DNA methylation, non-coding RNA, etc.)；Development of novel animal models of biliary atresia；Metagenomics in biliary atresia
●the pathogenesis and pediatric surgical treatment of embryonic diseases (malformation and tumors)
6.Neurosurgery direction
●Research on neurogenic tumor genes
●Neural development and artificial intelligence
7.Liver disease direction
●Identification of new pathogenic genes of cholestasis
●Finding biomarkers suggest the diagnosis and prognosis of cholestasis
●Pathogenesis and new therapeutic targets of hereditary cholestasis
●Directed differentiation of iPS hepatocytes
8.Dermatology direction:
●Molecular mechanism and treatment of genodermatosis.
●Molecular mechanism of atopic dermatitis.
9.Child Health direction
●Early diagnosis and treatment of autism spectrum disorder
10.Radiology direction
●Analysis of brain function and structure in children with brain injury
●Tumor imagingomics
●Artificial intelligence analysis of growth and development images
11.Other directions
●Regulatory mechanisms and biological/pathological functions of the Hippo pathway, modeling and molecular targeting of cancers, and cell migration/invasion
●High throughput screening and biological function analysis of membrane protein interaction
●Development of drugs and antibodies for tumor immunotherapy
●Big data analysis of protein interaction
●The key epigenetic regulation mechanism of cerebral nerve development
●Pathological mechanism of brain glioma in children
●Differentiation and migration mechanism of neural crest cells
The professors of our research fields
Guoying Huang, Yonghao Gui,Yi Wang, Hong Xu, Shan Zheng, Chao Chen, Jianshe Wang, Weili Yan, Liling Qian, Faxing Yu, Min Luo, Weijun Feng, Hao Li, Jia Rao, Xiu Xu, Kuiran Dong, Zhongwei Qiao, Taosheng Huang, Fang Liu, Qian Shen, Rui Dong, Yufeng Zhou, Jianshe Wang, Hongquan Geng, Ming Li, Zhiping Li
